Study on the pharmacokinetics of enrofloxacin in the Chinese mitten-handed crab, Eriocheir sinensis, after different administration regimes
|
|
Jingbo Z, Guanghong W, Yong M, Xinglian X
|
|
Enrofloxacin
|
|
Crab, Chinese mitten-handed
|
|
2008
|
|
50
|
|
hepatopancreas
|
|
91
|
|
17
|
|
Freshwater
|
|
30 mg/L for 24h
|
|
BATH
|
|
T1/2 alpha=0.2. AUC=956. Intramuscular administrated enrofloxacin (ENR) in muscle absorbed and eliminated faster than bath treatment and oral administration. ENR levels in hepatopancreas and muscle following IM injection were higher than those following PO administration. The metabolite ciprofloxacin (CIP) was much higher in hepatopancreas than muscle. CIP peaked at 5.95ug/g at 36h.
|
|
0.0314 L/kg/h
|
|
0.72 L/kg
|
|
Ciprofloxacin
|
|
Aquaculture Research 39: 1210-1215
|
|
http://dx.doi.org/10.1111/j.1365-2109.2008.01985.x
|
|
Eriocheir sinensis
|
|
Antibiotic-Quinolone
|
|
49.74
|
|
80.3-102.3
|
|
17+/-1
|
|
30mg/L - 24h
|
|
HPLC
|
|
Jingbo Z, Guanghong W, Yong M, Xinglian X
|
|