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Title:  Study on the pharmacokinetics of enrofloxacin in the Chinese mitten-handed crab, Eriocheir sinensis, after different administration regimes
Authors:  Jingbo Z, Guanghong W, Yong M, Xinglian X
Drug:  Enrofloxacin
Fish species:  Crab, Chinese mitten-handed
Date:  2008
t1/2-hr:  86
Sample:  muscle
Ave Weight (gm):  91
Ave Water temp (°C):  17
Water:  Freshwater
Dosage:  3 mg/kg
Route:  IM
Comments:  T1/2 alpha=1.2. AUC=161. Intramuscular administrated enrofloxacin (ENR) in muscle absorbed and eliminated faster than bath treatment and oral administration. ENR levels in hepatopancreas and muscle following IM injection were higher than those following PO administration. The metabolite ciprofloxacin (CIP) was much higher in hepatopancreas than muscle. CIP peaked at 0.24 ug/g at 72h.
Cl:  0.019 L/kg/h
Vc:  1.23 L/kg
Metabolites:  Ciprofloxacin
Citation:  Aquaculture Research 39: 1210-1215
Link:  http://dx.doi.org/10.1111/j.1365-2109.2008.01985.x  Opens a new window
Genus Species:  Eriocheir sinensis
Drug Class:  Antibiotic-Quinolone
t1/2-detail:  85.71
Wt gm-detail:  80.3-102.3
Water temp (°C)-detail:  17+/-1
Dosage-detail:  0.1 mL ENR = 3mg/mL
Method:  HPLC
Authors-red:  Jingbo Z, Guanghong W, Yong M, Xinglian X