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U.S. Department of Health and Human Services

PhishPharm - Detail

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Title:  A pharmacokinetic analysis of the effect of temperature on the accumulation of di-2-ethylhexyl phthalate (DEHP) in sheepshead minnow.
Authors:  Karara AH, Hayton WL
Drug:  DEHP-(Di-2-Ethylhexyl Phthalate)
Fish species:  Minnow, sheepshead
Date:  1989
t1/2-hr:  910
Sample:  whole body
Ave Weight (gm):  3
Ave Water temp (°C):  23
Water:  Saltwater
Dosage:  60 ng/ml 2-96 h
Route:  BATH
Comments:  Greatest metabolic clearance at 29C. Bioconcentration factor increased with increasing temperature. (14)C-DEHP
Cl:  381+/-1 L/kg/h
Vd:  v1=69, v2=19,000 L/kg
Citation:  Aquatic Toxicology 15:27-36
Link:  http://dx.doi.org/10.1016/0166-445X(89)90003-9  Opens a new window
Genus Species:  Cyprinodon variegatus variegatus
Drug Class:  Organic-Phtalate
t1/2-detail:  909.6 h
Wt gm-detail:  1-5 g
Water temp (°C)-detail:  23 C
Dosage-detail:  60 ng/ml for 2-96 h
Method:  GC, Rad
Authors-red:  Karara AH, Hayton WL