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Title:  Gender differences in the effect of salinity on aldicarb uptake, elimination, and in vitro metabolism in Japanese medaka, Oryzias latipes.
 
Authors:  El-Alfy AT, Bernache E, Schlenk D
 
Drug:  Aldicarb
 
Fish species:  Japanese rice fish (Medaka)
 
Date:  2002
 
t1/2-hr:  30
 
Sample:  whole body
 
Ave Weight (gm):  0.43
 
Ave Water temp (°C):  25
 
Water:  Saltwater
 
Dosage:  0.25 mg/l 24 h
 
Route:  BATH
 
Comments:  Salinity 20 ppt. Acclimated 2 weeks. aldicarb (14)C.Males alpha t 1/2=1.3, Beta t 1/2=29 h. Females alpha t 1/2=0.9, Beta t 1/2=31 h. Salinity did not have an effect on beta elimination in either males or females.
 
Metabolites:  Aldicarb sulfoxide, sulfone, nitrile, Unknown metabolite
 
Citation:  Aquatic Toxicology 61:225-232
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12359392&query_hl=3  Opens a new window
 
Genus Species:  Oryzias latipes
 
Drug Class:  Carbamate-Pesticide
 
t1/2-detail:  Males alpha t 1/2=1.3, Beta t 1/2=29 h. Females alpha t 1/2=0.9, Beta t 1/2=31.
 
Wt gm-detail:  0.39-0.47 g
 
Water temp (°C)-detail:  25 C
 
Dosage-detail:  0.25 mg/l 24 h
 
Method:  Rad
 
Authors-red:  El-Alfy AT, Bernache E, Schlenk D
 
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