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U.S. Department of Health and Human Services

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Title:  Gender differences in the effect of salinity on aldicarb uptake, elimination, and in vitro metabolism in Japanese medaka, Oryzias latipes.
 
Authors:  El-Alfy AT, Bernache E, Schlenk D
 
Drug:  Aldicarb sulfoxide
 
Fish species:  Japanese rice fish (Medaka)
 
Date:  2002
 
Sample:  liver
 
Ave Weight (gm):  0.43
 
Ave Water temp (°C):  25
 
Water:  Various*
 
Dosage:  0.25 mg/l 24 h
 
Route:  BATH
 
Comments:  Sulfoxide metabolite formed in vitro: males (nmole/hr/mg microsomal protein) = 1.5 ppt=nd, 12 ppt=59, 20ppt=79. Females 1.5 ppt=nd, 12.5ppt=99, 20ppt=181 (higher metabolic activation may cause the enhanced toxicity for females at the higher salinity)
 
Citation:  Aquatic Toxicology 61:225-232
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12359392&query_hl=3  Opens a new window
 
Genus Species:  Oryzias latipes
 
Drug Class:  Carbamate-Pesticide
 
Wt gm-detail:  0.39-0.47 g
 
Water temp (°C)-detail:  25 C
 
Dosage-detail:  0.25 mg/l 24 h
 
Method:  Rad
 
Authors-red:  El-Alfy AT, Bernache E, Schlenk D
 
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