Quick Links: Skip to main page content Skip to Search Skip to Topics Menu Skip to Common Links
  • Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

PhishPharm - Detail
  • Print
  • Share
  • E-mail
-
 
Title:  The human lipid regulator, gemfibrozil bioconcentrates and reduces testosterone in the goldfish, Carassius auratus.
 
Authors:  Mimeault C, Woodhouse AJ, Miao X.-S, Metcalfe CD, Moon TW, Trudeau VL
 
Drug:  Gemfibrozil
 
Fish species:  Carp, crucian (goldfish)
 
Date:  2005
 
t1/2-hr:  19
 
Sample:  blood, plasma
 
Ave Weight (gm):  26
 
Ave Water temp (°C):  18
 
Water:  Freshwater
 
Dosage:  5 ng/g sd
 
Route:  IP
 
Comments:  Conc in plasma during depuration: 24h=10,300, 48=4,000, 72h=1000, 96h= <515 ug/l. Authors estimated t 1/2 at 19 hr (vs human 1.5h)
 
Citation:  Aquatic Toxicology 73:44-54
 
Dep-time:  <5% of initial conc. remained after 96h
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15892991&query_hl=10  Opens a new window
 
Genus Species:  Carassius auratus auratus
 
Drug Class:  Lipid Regulator
 
t1/2-detail:  19 h
 
Wt gm-detail:  25.6+/-0.8g
 
Water temp (°C)-detail:  18+/-1°C
 
Dosage-detail:  5 ng/g sd
 
Method:  LC/MS, MS
 
Authors-red:  Mimeault C, Woodhouse AJ, Miao X.-S, Metcalfe CD, Moon TW, Trudeau VL
 
-
-