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U.S. Department of Health and Human Services

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Title:  Uptake, tissue distribution and excretion of domoic acid after oral exposure in coho salmon (Oncorhynchus kisutch).
 
Authors:  Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
 
Drug:  Domoic acid
 
Fish species:  Salmon, coho
 
Date:  2007
 
Sample:  blood, plasma
 
Ave Weight (gm):  464
 
Ave Water temp (°C):  11
 
Water:  Freshwater
 
Dosage:  13 mg/kg sd
 
Route:  PO
 
Comments:  All fish had measurable plasma domoic acid levels with in the first 15 min of oral exposure. Cmaxs of 500, 500, 450 and 300 ng/ml, at 24h,48h, 3h, and 12h, respectively, were recorded in four individual fish. Neuroexicitatory symptoms were not observed in any orally exposed fish. DA uptake patterns varied somewhat between the four fish. DA could still be detected 7d after oral gavage in the two fish that were still alive. Permanent intraarterial catheter implanted to quantify uptake and depuration rates.
 
Citation:  Aquatic Toxicology 81:266-274
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2006.12.009  Opens a new window
 
Genus Species:  Oncorhynchus kisutch
 
Drug Class:  Organic-Phycotoxin
 
Wt gm-detail:  464 +/- 73 g
 
Water temp (°C)-detail:  11 C
 
Dosage-detail:  13.1 +/- 1.1 mg/kg via oral gavage once.
 
Method:  ELISA
 
Authors-red:  Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
 
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