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U.S. Department of Health and Human Services

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Title:  Uptake, tissue distribution and excretion of domoic acid after oral exposure in coho salmon (Oncorhynchus kisutch).
 
Authors:  Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
 
Drug:  Domoic acid
 
Fish species:  Salmon, coho
 
Date:  2007
 
Sample:  brain
 
Ave Weight (gm):  464
 
Ave Water temp (°C):  11
 
Water:  Freshwater
 
Dosage:  13 mg/kg sd
 
Route:  PO
 
Comments:  Domoic acid Cmax in brain was around 100 ug/ml. Toxin levels were low and varied little. The level of domoic acid in brain after ICO (intraccoelomic)exposure were higher than domoic level in brain of orally galvaged fish. No neurotoxic activity in PO treated fish.
 
Citation:  Aquatic Toxicology 81:266-274
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2006.12.009  Opens a new window
 
Genus Species:  Oncorhynchus kisutch
 
Drug Class:  Organic-Phycotoxin
 
Wt gm-detail:  48 +/- 7g
 
Water temp (°C)-detail:  11-13 C
 
Dosage-detail:  A dose of 10 mg/kg administered in 250 ul volume once
 
Method:  ELISA
 
Authors-red:  Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
 
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