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U.S. Department of Health and Human Services

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Title:  Accumulation and elimination of methylmercury in Atlantic cod (Gadus morhua L.) following dietary exposure.
 
Authors:  Amlund H, Lundebye AK, Berntssen MHG
 
Drug:  Methylmercury
 
Fish species:  Cod, Atlantic
 
Date:  2007
 
t1/2-hr:  9048
 
Sample:  muscle
 
Ave Weight (gm):  561
 
Ave Water temp (°C):  11
 
Water:  Saltwater
 
Dosage:  0.95 +/- 0.03 ug/g in feed, 3 months
 
Route:  PO
 
Comments:  Water was provided via a flow-through system, and the amount was increased as the fish grew. Residues, after 3 months = 0.24 ug/g, compared to control = 0.031 ug/g. Cmax = 0.38 +/- 0.04 ug/g, Concentrations (ug/g) from graph: 20d = 0.05, 50d = 0.18, 65d = 0.27, 90d = 0.38, 120d = 0.38, 155d = 0.33, 177d = 0.32, Salinity 27 ppt. Abs effic=38%-most in protein fraction, elim constant K=0.18 Dosed for 3 months then depletion 3 months. T1/2 authors estimate 337 days. There was a lag period of 10 days for accumulation in muscle.
 
Citation:  Aquatic Toxicology 83:323-330
 
Dep-time:  >3 months
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2007.05.008  Opens a new window
 
Genus Species:  Gadus morhua
 
Drug Class:  Metal-Mercury
 
t1/2-detail:  377d
 
Wt gm-detail:  initial 325+/-93 end=796+/-196g
 
Water temp (°C)-detail:  11.1+/- 1.3 C
 
Dosage-detail:  0.95 +/- 0.03 ug/g in feed, 3 months
 
Method:  ICP, MS
 
Authors-red:  Amlund H, Lundebye AK, Berntssen MHG
 
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