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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics, bioavailability, distribution, and metabolism of sulfadimethoxine in the rainbow trout (Oncorhynchus mykiss).
 
Authors:  Kleinow KM, Beilfuss WL, Jarboe HH, Droy BF, Lech JJ
 
Drug:  Sulfadimethoxine
 
Fish species:  Trout, rainbow
 
Date:  1992
 
t1/2-hr:  17
 
Sample:  blood, plasma
 
Ave Weight (gm):  637
 
Ave Water temp (°C):  13
 
Water:  Freshwater
 
Dosage:  42 mg/kg sd
 
Route:  IVC
 
Comments:  t1/2 alpha=0.38 +/- 0.06 h, bioavailability=63 +/- 9.2%. Sulfadimethoxine-(35S). Residue at 4h=1.48, 12 hr= 54.18, 72 h= 9.23, 336 h= nd (ug/ml).
 
Protein binding:  15.8 +/-5.1%
 
Cl:  0.0227 L/kg/h
 
Vd:  0.50 L/kg
 
Metabolites:  N4-A-SDM
 
Citation:  Canadian J. Fisheries and Aquatic Sciences 49:1070-1077
 
Link:  http://www.nrcresearchpress.com/doi/abs/10.1139/f92-118  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  17 +/- 1.5 h
 
Wt gm-detail:  180-650 or 650-1094g
 
Water temp (°C)-detail:  13 +/-1 C
 
Dosage-detail:  42 mg/kg sd
 
Method:  HPLC-Rad
 
Authors-red:  Kleinow KM, Beilfuss WL, Jarboe HH, Droy BF, Lech JJ
 
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