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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Bioaccumulation and elimination of tetrachlorobenzyltoluene (TCBT) by the rat and by fish.
 
Authors:  Bouraly M, Millischer RJ
 
Drug:  Toluene-(TCBT-Tetrachlorobenzyltoluene)
 
Fish species:  Danio, zebra (zebrafish)
 
Date:  1989
 
t1/2-hr:  624
 
Sample:  whole body
 
Ave Weight (gm):  0
 
Ave Water temp (°C):  0
 
Water:  Freshwater
 
Dosage:  1 mg/ml 30 d
 
Route:  BATH
 
Comments:  Tetrachlorobenzyltoluene mixture of various isomers. Flowthrough study at 1 L/hr 1 mg/ml. 30 day bio-accumulation period followed by 30 day elimination period. Accumulation: d0+3h=6.5, d3=225, d7=352, d15=642, d30=727. Depletion:d32=990, d39=840, d50=635, d60=422 ug/g. Depuration of 50% by approx 26d. 12% mortality rate. Bioconc. factor d3=325, d7=420, d15=1065, d30=988.
 
Citation:  Chemosphere 18:2051-2063
 
Dep-time:  50% gone by 26 days, 95% estimated at 115 days.
 
Link:  http://dx.doi.org/10.1016/0045-6535(89)90486-4  Opens a new window
 
Genus Species:  Danio rerio
 
Drug Class:  Organic-Hydrocarbon
 
Wt gm-detail:  not specified
 
Water temp (°C)-detail:  21+/-1°C
 
Dosage-detail:  1 mg/ml flow rate-1L/hr for 30 d
 
Method:  GC
 
Authors-red:  Bouraly M, Millischer RJ
 
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