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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of morphine in fish: Winter flounder (Pseudopleuronectes americanus) and seawater-acclimated rainbow trout (Oncorhyncus mykiss).
 
Authors:  Newby NC, Mendonca PC, Gamperl K, Stevens ED
 
Drug:  Morphine
 
Fish species:  Trout, rainbow
 
Date:  2006
 
t1/2-hr:  14
 
Sample:  blood, plasma
 
Ave Weight (gm):  1003
 
Ave Water temp (°C):  10
 
Water:  Saltwater
 
Dosage:  39 mg/kg sd
 
Route:  IP
 
Comments:  A = 82.5 +/- 8.5 mg/L, ± = 0.500 +/- 0.032 per hour, B = 4.08 +/- 1.23 mg/L, ² = 0.0527 +/- 0.0051 per hour, T1/2dist = 1.43 +/- 0.09 h, AUCexpo = 245 +/- 36 mg h/L, AUCarea = 290 +/- 37 mg h/L, AUMCexpo = 1800 +/- 378 mg h2/L, AUMCarea = 2055 +/- 345 mg h2/L, MRTarea = 7.0 +/- 0.6 h. (Morphine Sulfate).
 
Cl:  0.153 L/kg/h
 
Citation:  Comparative Biochemistry and Physiology 143C:275-283
 
Link:  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16631414&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Analgesic-Morphine
 
t1/2-detail:  13.9 +/- 1.1
 
Wt gm-detail:  1003 +/- 64 g
 
Water temp (°C)-detail:  10 C
 
Dosage-detail:  39.3 +/- 0.1 mg/kg
 
Method:  ELISA
 
Authors-red:  Newby NC, Mendonca PC, Gamperl K, Stevens ED
 
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