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U.S. Department of Health and Human Services

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Title:  Influence of ormetoprim on the bioavailability, distribution, and pharmacokinetics of sulfadimethoxine in rainbow trout (Oncorhynchus mykiss).
 
Authors:  Droy BF, Tate T, Lech JJ, Kleinow KM.
 
Drug:  Sulfadimethoxine
 
Fish species:  Trout, rainbow
 
Date:  1989
 
t1/2-hr:  1
 
Sample:  blood, plasma
 
Ave Weight (gm):  540
 
Ave Water temp (°C):  14
 
Water:  Freshwater
 
Dosage:  SDM/ OMP 42/8 mg/kg sd
 
Route:  IVC
 
Comments:  Clearnce - 'intercompartmental=180.02 ml/kg/hr; total body= 23.04 ml/kg/hr, Vd= 503.85 ml/kg, peripheral compartment Vd= 342.25 ml/kg; Vc= 161.60 ml/kg; Sulfadimethoxine (14C) cannulated fish Ormetoprim (14C).
 
Cl:  0.023 L/kg/h
 
Vc:  0.02 L/kg
 
Vd:  0.50 L/kg
 
Metabolites:  N4-A-SDM
 
Citation:  Comparative Biochemistry and Physiology 94C:1:303-307
 
Link:  http://www.sciencedirect.com/science/article/pii/0742841389901837  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  0.04 h
 
Wt gm-detail:  444-640 g
 
Water temp (°C)-detail:  14 C
 
Dosage-detail:  SDM/ OMP 42/8 mg/kg sd
 
Method:  HPLC-Rad
 
Authors-red:  Droy BF, Tate T, Lech JJ, Kleinow KM.
 
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