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Title:
Accumulation and clearance of orally administered erythromycin and its derivative, azithromycin, in juvenile fall chinook salmon Oncorhynchus tshawytscha.
Authors:
Fairgrieve WT, Masada CL, McAuley WC, Peterson ME, Myers MS, Strom MS.
Drug:
Azithromycin
Fish species:
Salmon, chinook
Date:
2005
t1/2-hr:
353
Sample:
whole body
Ave Weight (gm):
0
Ave Water temp (°C):
10
Water:
Freshwater
Dosage:
30 mg/kg/d 14 d
Route:
PO
Comments:
Approx. residue after one 14 d treatment period = 45 ug/g. Average tissue concentrations: 28d= 19.0, 77d= 34.5 and 127d =44.9 ug/g. 35d post-exposure, concentration ranged from 4.7 to 7.9ug/g. No significant effect of mulitple exposure on whole body antibiotic concentration. No histopathologically significant lesion in trunk kidney and other organ tissues. Tissue concentration varied between 19.0 ug/g in fry to 44.9 ug/g in smolts. The smallest fish (0.5-0.6g) received one treatment, medium sized (3.0-5.2 g) received two, and the largest fish (11.1-13.0g) received three treatments before sampling. Although it appears that accumulation was higher in the larger fish, the data was not statistically significant. Elimination kinetics followed a single-phase exponential decay model.
Citation:
Diseases of Aquatic Organisms 64:99-106
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15918472&query_hl=9
Genus Species:
Oncorhynchus tshawytscha
Drug Class:
Antibiotic-Macrolide
t1/2-detail:
14.7 d
Wt gm-detail:
11.1-13.0 g
Water temp (°C)-detail:
10 C
Dosage-detail:
30 mg/kg/d 14 d
Method:
Micro
Authors-red:
Fairgrieve WT, Masada CL, McAuley WC, Peterson ME, Myers MS, Strom MS.
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