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U.S. Department of Health and Human Services

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Title:  Accumulation and clearance of orally administered erythromycin and its derivative, azithromycin, in juvenile fall chinook salmon Oncorhynchus tshawytscha.
 
Authors:  Fairgrieve WT, Masada CL, McAuley WC, Peterson ME, Myers MS, Strom MS.
 
Drug:  Azithromycin
 
Fish species:  Salmon, chinook
 
Date:  2005
 
t1/2-hr:  353
 
est:  est
 
Sample:  whole body
 
Ave Weight (gm):  0
 
Ave Water temp (°C):  10
 
Water:  Freshwater
 
Dosage:  30 mg/kg/d 14 d repeated once after about 32 d post treatment
 
Route:  PO
 
Comments:  Approx. residues after first treatment period = 35 ug/g, and after 2nd period= 42 ug/g. Average tissue concentrations: 28d= 19.0, 77d= 34.5 and 127d =44.9 ug/g. 35d post-exposure, concentration ranged from 4.7 to 7.9ug/g. No significant effect of mulitple exposure on whole body antibiotic concentration. No histopathologically significant lesion in trunk kidney and other organ tissues. Tissue concentration varied between 19.0 ug/g in fry to 44.9 ug/g in smolts. The smallest fish (0.5-0.6g) received one treatment, medium sized (3.0-5.2 g) received two, and the largest fish (11.1-13.0g) received three treatments before sampling. Although it appears that accumulation was higher in the larger fish, the data was not statistically significant. Elimination kinetics followed a single-phase exponential decay model.
 
Citation:  Diseases of Aquatic Organisms 64:99-106
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15918472&query_hl=9  Opens a new window
 
Genus Species:  Oncorhynchus tshawytscha
 
Drug Class:  Antibiotic-Macrolide
 
Wt gm-detail:  3-5.2 g and 11.1-13 g
 
Water temp (°C)-detail:  10 C
 
Dosage-detail:  30 mg/kg/d 14 d repeated once after about 32 d post treatment
 
Method:  Micro
 
Authors-red:  Fairgrieve WT, Masada CL, McAuley WC, Peterson ME, Myers MS, Strom MS.
 
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