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U.S. Department of Health and Human Services

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Title:  Accumulation and clearance of orally administered erythromycin and its derivative, azithromycin, in juvenile fall chinook salmon Oncorhynchus tshawytscha.
 
Authors:  Fairgrieve WT, Masada CL, McAuley WC, Peterson ME, Myers MS, Strom MS.
 
Drug:  Erythromycin
 
Fish species:  Salmon, chinook
 
Date:  2005
 
Sample:  whole body
 
Ave Weight (gm):  0
 
Ave Water temp (°C):  10
 
Water:  Freshwater
 
Dosage:  100 mg/kg/d 28 d repeated twice, each after about 12-20 d post treatment
 
Route:  PO
 
Comments:  Approx. residues after first treatment period = 0.2 ug/g, after 2nd period= 2.5 ug/ and after 3rd period=10.4 ug/g. Average tissue concentrations: 42d= 0.2, 91d= 2.5 and 141d = 10.4 ug/g. Drug was eliminated within 21 days post-exposure. No significant effect of mulitple exposure on whole body antibiotic concentration. No histopathologically significant lesion in trunk kidney and other organ tissues. Half life could not be estimated because tissue concentrations were below tissue limit by 2nd post-treatment sampling. Tissue concentration varied between 0.2 ug/g in fry to 10.4 ug/g in smolts. The smallest fish (0.5-1.3g) received one treatment, medium sized (3.0-5.6g) received two, and the largest fish (11.0-15.3g) received three treatments before sampling. Although it appears that accumulation was higher in the larger fish, the data was not statistically significant.other dosage regimens).
 
Citation:  Diseases of Aquatic Organisms 64:99-106
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15918472&query_hl=9  Opens a new window
 
Genus Species:  Oncorhynchus tshawytscha
 
Drug Class:  Antibiotic-Macrolide
 
Wt gm-detail:  0.5-0.6g; 3-5.2 g; 11.1-13 g
 
Water temp (°C)-detail:  10 C
 
Dosage-detail:  100 mg/kg/d 28 d repeated twice, each after about 12-20 d post treatment
 
Method:  Micro
 
Authors-red:  Fairgrieve WT, Masada CL, McAuley WC, Peterson ME, Myers MS, Strom MS.
 
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