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U.S. Department of Health and Human Services

PhishPharm - Detail

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Title:  Methyl mercury toxicokinetics in channel catfish (Ictalurus punctatus) and largemouth bass (Micropterus salmoides) after intravascular administration.
Authors:  Schultz IR, Newman MC
Drug:  Methylmercury
Fish species:  Bass, largemouth black
Date:  1997
t1/2-hr:  905
Sample:  blood, plasma
Ave Weight (gm):  696
Ave Water temp (°C):  21
Water:  Freshwater
Dosage:  0.47 mg/kg sd
Route:  IV
Comments:  Salinity at 1ppt. Fish received a 2-h treatment in a 0.25 mg/L solution of malachite green. Fish anesthetized with 100 mg/L MS-222. AUC=97,600 ng/ml*h, Cmax=2,361 ng/ml, Mean Residence Time=1,054h.
Protein binding:  0.0025
Cl:  0.0057 ml/h/g
Vd:  6.2 ml/g
Citation:  Environmental Toxicology and Chemistry 16:990-996
Link:  http://dx.doi.org/10.1002/etc.5620160518  Opens a new window
Genus Species:  Micropterus salmoides
Drug Class:  Metal-Mercury
t1/2-detail:  905+/-189
Wt gm-detail:  696+/-130g
Water temp (°C)-detail:  20-22C
Dosage-detail:  0.47 mg/kg sd
Method:  AAS
Authors-red:  Schultz IR, Newman MC