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U.S. Department of Health and Human Services

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Title:  Methyl mercury toxicokinetics in channel catfish (Ictalurus punctatus) and largemouth bass (Micropterus salmoides) after intravascular administration.
 
Authors:  Schultz IR, Newman MC
 
Drug:  Methylmercury
 
Fish species:  Bass, largemouth black
 
Date:  1997
 
t1/2-hr:  905
 
Sample:  blood, plasma
 
Ave Weight (gm):  696
 
Ave Water temp (°C):  21
 
Water:  Freshwater
 
Dosage:  0.47 mg/kg sd
 
Route:  IV
 
Comments:  Salinity at 1ppt. Fish received a 2-h treatment in a 0.25 mg/L solution of malachite green. Fish anesthetized with 100 mg/L MS-222. AUC=97,600 ng/ml*h, Cmax=2,361 ng/ml, Mean Residence Time=1,054h.
 
Protein binding:  0.0025
 
Cl:  0.0057 ml/h/g
 
Vd:  6.2 ml/g
 
Citation:  Environmental Toxicology and Chemistry 16:990-996
 
Link:  http://dx.doi.org/10.1002/etc.5620160518  Opens a new window
 
Genus Species:  Micropterus salmoides
 
Drug Class:  Metal-Mercury
 
t1/2-detail:  905+/-189
 
Wt gm-detail:  696+/-130g
 
Water temp (°C)-detail:  20-22C
 
Dosage-detail:  0.47 mg/kg sd
 
Method:  AAS
 
Authors-red:  Schultz IR, Newman MC
 
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