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U.S. Department of Health and Human Services

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Title:  Estimating the oral bioavailability of methylmercury to channel catfish (Ictalurus punctatus).
 
Authors:  McCloskey JT, Schultz IR, Newman MC
 
Drug:  Methylmercury
 
Fish species:  Catfish, channel
 
Date:  1998
 
t1/2-hr:  477
 
Sample:  blood
 
Ave Weight (gm):  840
 
Ave Water temp (°C):  21
 
Water:  Freshwater
 
Dosage:  0.44 mg/kg sd
 
Route:  IV
 
Comments:  Salinity at 1ppt. Fish received a 2-h treatment in a 0.25 mg/L solution of malachite green prior to study. Fish anesthetized with 150 ml/L MS-222. AUC=129,240 ng/ml*h, Cmax=5,498 ng/ml, Mean Residence Time=916h. The same fish were used for both routes of administration.
 
Cl:  0.0042 ml/h/g
 
Vd:  4.0 ml/g
 
Citation:  Environmental Toxicology and Chemistry 17:1524-1529
 
Link:  http://dx.doi.org/10.1002/etc.5620170812  Opens a new window
 
Genus Species:  Ictalurus punctatus
 
Drug Class:  Metal-Mercury
 
t1/2-detail:  477+/-163h
 
Wt gm-detail:  840+/-170g
 
Water temp (°C)-detail:  21.2+/-0.7C
 
Dosage-detail:  0.44 mg/kg
 
Method:  AAS
 
Authors-red:  McCloskey JT, Schultz IR, Newman MC
 
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