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Title:  Estimating the oral bioavailability of methylmercury to channel catfish (Ictalurus punctatus).
Authors:  McCloskey JT, Schultz IR, Newman MC
Drug:  Methylmercury
Fish species:  Catfish, channel
Date:  1998
t1/2-hr:  818
Sample:  blood
Ave Weight (gm):  840
Ave Water temp (°C):  21
Water:  Freshwater
Dosage:  0.53 mg/kg sd
Route:  PO
Comments:  Salinity at 1ppt. Fish received a 2-h treatment in a 0.25 mg/L solution of malachite green prior to study. Fish anesthetized with 150 ml/L MS-222. AUC=29,299 ng/ml*h, Cmax=86 ng/ml, Tmax=38h. Compartamental Bioavailability estimated to be 29%. The same fish were used for both routes of administration.
Citation:  Environmental Toxicology and Chemistry 17:1524-1529
Link:  http://dx.doi.org/10.1002/etc.5620170812  Opens a new window
Genus Species:  Ictalurus punctatus
Drug Class:  Metal-Mercury
t1/2-detail:  818+/-202h
Wt gm-detail:  840+/-170g
Water temp (°C)-detail:  21.2+/-0.7C
Dosage-detail:  0.53 mg/kg sd
Method:  AAS
Authors-red:  McCloskey JT, Schultz IR, Newman MC