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U.S. Department of Health and Human Services

PhishPharm - Detail

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Title:  Bioconcentration, biotransformation, and elimination of polycyclic aromatic hydrocarbons in sheepshead minnows (Cyprinodon variegatus) exposed to contaminated seawater.
Authors:  Jonsson G, Bechmann RK, Bamber SD, Baussant T.
Drug:  Phenanthrene-(9-Ethyl phenanthrene)
Fish species:  Minnow, sheepshead
Date:  2004
t1/2-hr:  96
est:  est
Sample:  whole body
Ave Weight (gm):  3
Ave Water temp (°C):  25
Water:  Saltwater
Dosage:  0.06 ug/l 36 d*
Route:  BATH
Comments:  Study used a mixture of 8 PAH's- at low (7.57 ug/l) and high concentration (72.3 ug/L). Salinity 34 ppt. Concentrations generally peaked and reached a steady state btwn 2-7d of the 36 d exposure, at approx= 1000 ug/g. K2=0.6/d BCF=428.
Metabolites:  glucuronide, hydroxylated
Citation:  Environmental Toxicology and Chemistry 23:1538-1548
Dep-time:  95 % elim by day 4.9
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15376540&query_hl=21  Opens a new window
Genus Species:  Cyprinodon variegatus variegatus
Drug Class:  Organic-Hydrocarbon
t1/2-detail:  < 4 d est from graph
Wt gm-detail:  2.47+/- 1.23 g
Water temp (°C)-detail:  25
Dosage-detail:  0.06 ug/l 36 d*
Method:  GC/MS
Authors-red:  Jonsson G, Bechmann RK, Bamber SD, Baussant T.