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U.S. Department of Health and Human Services

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Title:  Bioconcentration and elimination of avermectin B1 in sturgeon.
 
Authors:  Shen J, Zhang Q, Ding S, Zhang S, Coats JR
 
Drug:  Avermectin B1
 
Fish species:  Sturgeon
 
Date:  2005
 
t1/2-hr:  104
 
Sample:  muscle
 
Ave Weight (gm):  36
 
Ave Water temp (°C):  20
 
Water:  Freshwater
 
Dosage:  1 ng/ml 22d
 
Route:  BATH
 
Comments:  Residue dose day22= 38.29+/- 0.1.5ng/g. Withdrawall d22= 2.1 +/-0.19 ng/g, d44=ND. The estimated value of bioconcentration factor was 41 L/kg. BCF for both the the high and low concentrations was not significantly different indicating that Avermectin B1 does not strongly bioconcentrate in aquatic organisms and would not be expected to biomagnify in the food chain. Uptake constant=6.5, elim constant 0.16. Average recoveries of fortified water samples were 80.5% +/- 5.1% for 1 ng/mL, 83.7% +/- 3.8% for 4 ng/mL, and 89.1 +/- 4.0% for 7 ng/mL.
 
Citation:  Environmental Toxicology and Chemistry 24: 396-399
 
Link:  http://www.ncbi.nlm.nih.gov/pubmed/15720000?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum  Opens a new window
 
Genus Species:  Acipenser sp
 
Drug Class:  Antiparasitic-Avermectin
 
Wt gm-detail:  35.8+/-4.6g
 
Water temp (°C)-detail:  20+/-1 C
 
Dosage-detail:  Flow through 0.2 ng/ml for 22 days.
 
Method:  HPLC
 
Authors-red:  Shen J, Zhang Q, Ding S, Zhang S, Coats JR
 
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