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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Total residue depletion and metabolic profile of selected drugs in catfish: Benzocaine.
 
Authors:  Hayton WL (1995b)
 
Drug:  Benzocaine
 
Fish species:  Catfish, channel
 
Date:  1995
 
Sample:  blood, plasma
 
Ave Weight (gm):  594
 
Ave Water temp (°C):  25
 
Water:  Freshwater
 
Dosage:  *see comment
 
Route:  BATH
 
Comments:  Dose-70 mg/L for 5 min, then 35 mg/L for 30 min- *metabolites were observed in all tissues at 0 h and 4 h depuration; Residues: 0 h depuration= 47.1 ppm, 4h= 2.92. During depuration the concentration of radioactivity fell rapidly in all tissues and fluids but bile - reaching about 1 % or less of the 0 depuration time by 25 hr. Starting at about 25 h depuration, residue concentration in all tissues and fluids sampled appeared to enter log-linear phase having half-life of about 8 d, Benzocaine (14C)
 
Metabolites:  Acetylated benzocaine, acetyl-p-aminobenzoic acid*
 
Citation:  Final FDA Report. Contract 223-91-7015. Vol 2
 
Link:  none  Opens a new window
 
Genus Species:  Ictalurus punctatus
 
Drug Class:  Anesthetic-Benzocaine
 
Wt gm-detail:  594 +/- 134 g
 
Water temp (°C)-detail:  25 C
 
Dosage-detail:  70 mg/L for 5 min, then 35 mg/L for 30 min
 
Method:  HPLC-Rad
 
Authors-red:  Hayton WL (1995b)
 
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