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Title:
Total residue depletion and metabolic profile of selected drugs in salmonids: Acriflavine and Proflavine.
Authors:
Hayton WL (1997e)
Drug:
Proflavine
Fish species:
Trout, rainbow
Date:
1997
t1/2-hr:
26
Sample:
blood, plasma
Ave Weight (gm):
601
Ave Water temp (°C):
12
Water:
Freshwater
Dosage:
4 mg/l 4 hr
Route:
BATH
Comments:
Metabolites only identified in kidney, liver and bile. Concentration of radioactivity (ppb) at 4h exposure = 52.3, withdrawal day 2 = 11.0, day 4= 10.7, withdrawal day 8 = 4.31. Proflavine (14C).
Protein binding:
0.809
Cl:
1.05 L/kg/h
Vd:
28.2 L/kg
Metabolites:
3-N-glucuronosyl proflavine, 3-N-glucuronosyl, 6-N-acetyl proflavine, 3-N-acetyl proflavine
Citation:
Final FDA Report. Contract 223-93-7014. Vol 1. Study 728363-004.
Link:
none
Genus Species:
Oncorhynchus mykiss
Drug Class:
Organic-Dye
t1/2-detail:
26 h
Wt gm-detail:
601 +/- 122 g
Water temp (°C)-detail:
12 C
Dosage-detail:
4 ppm 4 hr
Method:
HPLC-Rad
Authors-red:
Hayton WL (1997b)
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