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U.S. Department of Health and Human Services

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Title:  Depletion of oxytetracycline from subadult penaeid shrimp: Analytical Chemistry.
 
Authors:  Carson MC, Ngoh MA, Kijak PJ, Heller DN, Williams RR
 
Drug:  Oxytetracycline
 
Fish species:  Shrimp, whiteleg
 
Date:  1998
 
t1/2-hr:  13
 
Sample:  muscle
 
Ave Weight (gm):  11
 
Water:  Freshwater
 
Dosage:  22.5 mg/kg BID 14 d
 
Route:  PO
 
Comments:  PO in feed - nominal 4.5 g/kg feed, actual measured conc 3.24 g/kg feed. Shrimp were approx 11 g and fed 6-10%BWT. Residues ppm wd = 0h=3.85, 12 h=2.99, 24 h=1.83, 36h=1.50, 48h=0.28, 72h <0.25 (LOQ) - most estimated <0.1. t1/2 estimated by authors - initial = 21 hrs, terminal 10 hrs, overall about 13 hrs.
 
Citation:  Final FDA Report. Study 333.01
 
Link:  none  Opens a new window
 
Genus Species:  Litopenaeus vannamei
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  initial=21h, terminal =10h, overal=13h
 
Wt gm-detail:  > 11 g
 
Water temp (°C)-detail:  Texas ponds in August 1998
 
Dosage-detail:  22.5 mg/kg BID 14 d (6-10% BW divided BID of 4.5 g/kg feed
 
Method:  HPLC
 
Authors-red:  Carson MC, Ngoh MA, Kijak PJ, Heller DN, Williams RR
 
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