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Title:
Involement of multiple biotranformation processes in the metabolic elimination of testosterone by juvenile and adult fathead minnows (Pimephales promelas).
Authors:
Parks LG, LeBlanc GA
Drug:
Testosterone
Fish species:
Minnow, fathead
Date:
1998
t1/2-hr:
2
est:
est
Sample:
whole body
Ave Water temp (°C):
23
Water:
Freshwater
Dosage:
1.0 uM up to 4h
Route:
BATH
Comments:
(14C)-Testosterone. Juveniles accumualte max 100,000 nmol/g by 2h. Adult males max 12,000 by 2h. Adult females eliminated androstanediols at greater rate than males and juveniles eliminated nearly all metabolites at a greater rate than adults. Androstanediols Cl adult female - 600 pmol/h/g .
Cl:
600 pmol/h/g
Metabolites:
Androstenedione, DHT, 3-Androstanediol (alpha &beta), 11-ketotestosterone, hydroxytestosterone(6 beta and 16 beta), Androstenetriols, conjugated forms.
Citation:
Genearal and Comparative Endocrinology 112:69-79
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9748405&query_hl=13
Genus Species:
Pimephales promelas
Drug Class:
Hormone-Testosterone
t1/2-detail:
< 2h from graph
Wt gm-detail:
adults and juveniles-2-3 months
Water temp (°C)-detail:
22-23 C
Dosage-detail:
1.0 uM up to 4h
Method:
GC/MS, Rad, TLC
Authors-red:
Parks LG, LeBlanc GA
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