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Title:
Evaluation of a method of intracoelomic catheterization in koi.
Authors:
Lewbart G, Butkus D, Papich M, Coleman A, Krum H, Noga E
Drug:
Enrofloxacin
Fish species:
Carp, common (koi)
Date:
2005
t1/2-hr:
71
Sample:
blood, plasma
Ave Weight (gm):
613
Ave Water temp (°C):
19
Water:
Freshwater
Dosage:
10 mg/kg sd
Route:
IP
Comments:
Cipro metabolite not found. Cmax = 4.72 g/mL (at 12 hours) Concentrations from graph: 2h = 4.5, 4h = 4, 8h = 4, 12h = 4.5, 24h = 3.5, 48h = 3.3, 72h = 2.5. Elimination rate = 0.0098 L/h, Tmax = 12 h, AUC = 501.84 h g/mL, Vd/F reported = 1012.7 mL/kg, Cl reported = 9.96 ml/h/kg, AUMC = 52,118 h^2g/mL, MRT = 103.9 h. study compares IP with Intracoelomic Catheter.
Cl:
0.01
Vd:
1.012
Metabolites:
Ciprofloxacin
Citation:
J American Veterinary Medical Association 226:784-788
Link:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15776954&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Genus Species:
Cyprinus carpio
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
70.4551 h
Wt gm-detail:
212-1014 g
Water temp (°C)-detail:
18.5-19.5 C
Dosage-detail:
10 mg/kg sd
Method:
HPLC
Authors-red:
Lewbart G, Butkus D, Papich M, Coleman A, Krum H, Noga E
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