Quick Links: Skip to main page content
Skip to Search
Skip to Topics Menu
Skip to Common Links
U.S. Food & Drug Administration
Follow FDA
En Español
Search FDA
Home
Food
Drugs
Medical Devices
Radiation-Emitting Products
Vaccines, Blood & Biologics
Animal & Veterinary
Cosmetics
Tobacco Products
PhishPharm - Detail
FDA Home
PhishPharm
Detail
-
Please note:
JavaScript must be enabled for this application to work properly.
Check your settings
if you are unsure if your JavaScript is enabled.
Title:
Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii)
Authors:
Hou X, Shen J, Zhang S, Jiang H, Coats JR
Drug:
Sulfamethazine
Fish species:
Sturgeon, amur
Date:
2003
t1/2-hr:
24
Sample:
muscle
Ave Weight (gm):
28
Ave Water temp (°C):
20
Water:
Freshwater
Dosage:
0.10 mg/L 8 d
Route:
BATH
Comments:
BCF=1.19,relatively higher than the BCF at the 1.00 mg/L dose. uptake rate=20.16/h, elim rateK=16.8/h, Cmax aprox 0.15 mg/kg. 90% of the drug was eliminated within 3-4 days. No metabolite residue detected.
Metabolites:
N4-acetyl-SM2
Citation:
J. Agricultural and Food Chemistry 51:7725-7729
Dep-time:
approx 5 d
Link:
http://pubs.acs.org/cgi-bin/article.cgi/jafcau/2003/51/i26/pdf/jf030492+.pdf
Genus Species:
Acipenser schrenckii
Drug Class:
Antibiotic-Sulfa
t1/2-detail:
23.52 h,
Wt gm-detail:
28.2 +/- 5.1
Water temp (°C)-detail:
19-20 °C
Dosage-detail:
0.10 mg/L 8 d
Method:
HPLC
Authors-red:
Hou X, Shen J, Zhang S, Jiang H, Coats JR
-
-