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U.S. Department of Health and Human Services

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Title:  Kinetic analysis of oxytretracycline residues in Chinese mitten crab, Eriocheir sinensis, muscle following intramuscular administration.
 
Authors:  Feng Q, Gao T, Ji H, Jiang X, Liang T, Gu W, Wu G, Gao G, Wang W
 
Drug:  Oxytetracycline
 
Fish species:  Crab, Chinese mitten-handed
 
Date:  2010
 
t1/2-hr:  152
 
Sample:  muscle
 
Ave Weight (gm):  104
 
Ave Water temp (°C):  18
 
Water:  Freshwater
 
Dosage:  40 mg/kg sd
 
Route:  IM
 
Comments:  Peak OTC concentratration at 0.25 h = 80.22 ug/ml. AUC calculated to be 3479.37 ug/ml. MRT=200.46h. Authors estimated withdrawal time estimated to be 55.92 d.
 
Cl:  0.012 L/kg/h
 
Vc:  0.074 L/kg
 
Vd:  2.51 L/kg
 
Citation:  J. Fish Disease 33:639-647
 
Link:  http://dx.doi.org/10.1111/j.1365-2761.2010.01168.x  Opens a new window
 
Genus Species:  Eriocheir sinensis
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  alpha=4.38h, beta=151.13h
 
Wt gm-detail:  103.7+/- 7.4 g
 
Water temp (°C)-detail:  18 +/- 1C
 
Dosage-detail:  40 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Feng Q, Gao T, Ji H, Jiang X, Liang T, Gu W, Wu G, Gao G, Wang W
 
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