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Title:
A single-dose pharmocokinetic study of emamectin benzoate in cod, Gadus morhua L., held in sea water at 9C.
Authors:
Samuelsen OB
Drug:
Emamectin Benzoate
Fish species:
Cod, Atlantic
Date:
2010
t1/2-hr:
216
Sample:
blood, plasma
Ave Weight (gm):
150
Ave Water temp (°C):
9
Water:
Saltwater
Dosage:
0.05 mg/kg sd
Route:
IV
Comments:
Salinity at 33 ppt. Fish anesthetized by immersion in metomidate (5 mg/L). Fish killed by blow to the head. Mean residence time=385h. AUC=10478 h/ng*ml, Cmax=130 ng/ml.
Cl:
0.0059 L/kg*h
Vd:
1.839 L/kg
Citation:
J. Fish Diseases 33:137-142
Link:
http://dx.doi.org/10.1111/j.1365-2761.2009.01097.x
Genus Species:
Gadus morhua
Drug Class:
Antiparasitic-Avermectin
t1/2-detail:
alpha: 2.5h, beta:216h
Wt gm-detail:
100-200g
Water temp (°C)-detail:
9.0+/-0.5C
Dosage-detail:
50 ug/kg sd
Method:
HPLC
Authors-red:
Samuelsen OB
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