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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of morphine and its metabolites in freshwater rainbow trout (Oncorhynchus mykiss)
 
Authors:  Newby NC, Robinson JW, Vachon P, Beaudry F, Stevens ED
 
Drug:  Morphine
 
Fish species:  Trout, rainbow
 
Date:  2008
 
t1/2-hr:  18
 
Sample:  blood, plasma
 
Ave Weight (gm):  2269
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  40 mg/kg sd
 
Route:  IP
 
Comments:  Anaesthetic for surgery-benzocaine (25 mg/ml). Euthanized in buffered MS-222. AUC=202 (mg·h/L). MRT=14.7h. PK Data for M3G - t1/2 elim=107+/-38h, MRT=162h, AUC=160(est). Fresh water trout metabolize morphine more slowly than previously reported for sea water acclimated ones. They also metabolize morphine at a rate slower than in mammals (at least one order of magnitude). Only one metabolite was found - M3G which increased after injection and peaked about 2 days later.
 
Cl:  95+/-11
 
Vd:  1.3+/-.004
 
Metabolites:  Morphine-3-²-D-glucuronide (M3G)
 
Citation:  J. vet Pharmacol. Therap. 31: 117-127
 
Link:  http://www3.interscience.wiley.com/journal/119398671/abstract  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Analgesic-Morphine
 
t1/2-detail:  18.3+/-1.7
 
Wt gm-detail:  2269+/-137
 
Water temp (°C)-detail:  12+/-2 C
 
Dosage-detail:  40.1+/-0.1
 
Method:  LC, MS/MS
 
Authors-red:  Newby NC, Robinson JW, Vachon P, Beaudry F, Stevens ED
 
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