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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis, after a single i.v. injection and bath administration.
 
Authors:  Gore SR, Harms CA, Kukanich B, Forsythe J, Lewbart GA, Papich MG
 
Drug:  Enrofloxacin
 
Fish species:  Cuttlefish, European common
 
Date:  2005
 
t1/2-hr:  2
 
Sample:  blood, hemolymph
 
Ave Weight (gm):  115
 
Ave Water temp (°C):  25
 
Water:  Saltwater
 
Dosage:  5 mg/kg sd
 
Route:  IV
 
Comments:  Cipro metabolite was not found. Salinity 32% Hemolymph sampling - naïve pooling (all animals sampled before dose, 3 at times 0.5, 2, 6, 24, 72 and 3 at 1, 3, 12, 48, 72 h). AUC 17.69 ug.h/ml, MRT 1.36, t1/2 alpha=0.47, CL=4.71 ml/min/kg
 
Cl:  0.28 L/kg/h
 
Vd:  0.385 L/kg
 
Metabolites:  Ciprofloxacin
 
Citation:  J. Veterinary Pharmacology and Therapeutics 28:433-439
 
Link:  http://dx.doi.org/10.1111/j.1365-2885.2005.00684.x  Opens a new window
 
Genus Species:  Sepia officinalis
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  1.81 h
 
Wt gm-detail:  87.0-138.2 g
 
Water temp (°C)-detail:  25 C
 
Dosage-detail:  5 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Gore SR, Harms CA, Kukanich B, Forsythe J, Lewbart GA, Papich MG
 
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