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U.S. Department of Health and Human Services

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Title:  The complete analysis of oxytetracycline pharmacokinetics in farmed Pacific white shrimp (Litopenaeus vannamei).
 
Authors:  Chiayvareesajja S, Chandumpai A, Theapparat Y, Faroongsarng D.
 
Drug:  Oxytetracycline
 
Fish species:  Shrimp, whiteleg
 
Date:  2006
 
t1/2-hr:  21
 
Sample:  blood, hemolymph
 
Ave Weight (gm):  18
 
Ave Water temp (°C):  28
 
Water:  Saltwater
 
Dosage:  10 mg/kg sd
 
Route:  IS
 
Comments:  60% elimination by digestive gland. Salinity 20 +/-2 ppt. Drug could not be quantified past 170 hr. Cmax=32 ug/ml, Tmax=0 h, AUC=266,mean transit time=54h. T 1/2=20.74. Animals were synchronized for moulting. Using 2 compartment model t 1/2 alpha=0.23 h, beta=16.42 h, AUC=198 Vss=1.14mL/g for compartment 1, t 1/2 alpha=0.23 h, beta=19.16 h, AUC=162 for compartment 2,.
 
Citation:  J. Veterinary Pharmacology and Therapeutics 29:409-414
 
Dep-time:  >7 d
 
Link:  http://dx.doi.org/10.1111/j.1365-2885.2006.00785.x  Opens a new window
 
Genus Species:  Litopenaeus vannamei
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  20.74 h
 
Wt gm-detail:  14-22 g
 
Water temp (°C)-detail:  28+/- 2C
 
Dosage-detail:  10 ug/g sd
 
Method:  HPLC
 
Authors-red:  Chiayvareesajja S, Chandumpai A, Theapparat Y, Faroongsarng D.
 
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