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Title:  Comparative pharmacokinetics of oxytetracycline in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus).
 
Authors:  Grondel JL, Nouws JFM, Schutte AR, Driessens F
 
Drug:  Oxytetracycline
 
Fish species:  Trout, rainbow
 
Date:  1989
 
t1/2-hr:  6
 
Sample:  blood, plasma
 
Ave Weight (gm):  323
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  60 mg/kg sd
 
Route:  IV
 
Comments:  AUC = 3759+/- 306 ug h/ml. t 1/2 alpha=0.6 h, beta 6.3, gamma 89.5. Cl, Vc, and Vd were calculated in a model-independent way according to Baggot (1977).
 
Cl:  0.016 L/kg/h
 
Vc:  0.09+/-0.04 L/kg
 
Vd:  2.1+/-0.3 L/kg
 
Citation:  J. Veterinary Pharmacology and Therapeutics 12:157-162
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2746722  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  6.3+/-2.6 h
 
Wt gm-detail:  323+/-9 g
 
Water temp (°C)-detail:  12 C
 
Dosage-detail:  60 mg/kg sd
 
Method:  Micro
 
Authors-red:  Grondel JL, Nouws JFM, Schutte AR, Driessens F
 
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