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U.S. Department of Health and Human Services

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Title:  Comparative pharmacokinetics of oxytetracycline in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus).
 
Authors:  Grondel JL, Nouws JFM, Schutte AR, Driessens F
 
Drug:  Oxytetracycline
 
Fish species:  Trout, rainbow
 
Date:  1989
 
t1/2-hr:  95
 
Sample:  blood, plasma
 
Ave Weight (gm):  323
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  60 mg/kg sd
 
Route:  IM
 
Comments:  Bioavailability 85%. Injection in dorsal region. Blood sampled from caudal vein (0.2 ml). Cmax (mean max. plasma concentration) = 56.9 ug/ml at 4h.
 
Citation:  J. Veterinary Pharmacology and Therapeutics 12:157-162
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2746722  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  94.7+/-16 h
 
Wt gm-detail:  323+/-9 g
 
Water temp (°C)-detail:  12 C
 
Dosage-detail:  60 mg/kg sd
 
Method:  Micro
 
Authors-red:  Grondel JL, Nouws JFM, Schutte AR, Driessens F
 
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