• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

PhishPharm - Detail

  • Print
  • Share
  • E-mail
Title:  Pharmacokinetic and tissue distribution study of oxytetracycline in rainbow trout following bolus intravenous administration.
Authors:  Black WD, Ferguson HW, Byrne P, Claxton MJ
Drug:  Oxytetracycline
Fish species:  Trout, rainbow
Date:  1991
t1/2-hr:  82
Sample:  blood, serum
Ave Weight (gm):  375
Ave Water temp (°C):  10
Water:  Freshwater
Dosage:  5 mg/kg sd
Route:  IV
Comments:  Serum [] 96h post = 0.52+/-0.17mg/g; takes 408-654h for 97% of drug to disappear dep on 5 t1/2 or max t1/2 used. AUC 196.9 ug.h/ml
Cl:  0.025 L/kg/h
Vc:  0.019 L/kg
Vd:  2.99 L/kg
Citation:  J. Veterinary Pharmacology and Therapeutics 14:351-358
Dep-time:  408 h
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1774812&dopt=Abstract  Opens a new window
Genus Species:  Oncorhynchus mykiss
Drug Class:  Antibiotic-Tetracycline
t1/2-detail:  81.5h
Wt gm-detail:  300-450g
Water temp (°C)-detail:  10+/-0.5C
Dosage-detail:  5 mg/kg sd
Method:  Micro
Authors-red:  Black WD, Ferguson HW, Byrne P, Claxton MJ