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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of oxolinic acid in sea-bass, Dicentrarchus labrax (L., 1758), after a single rapid intravascular injection.
 
Authors:  Poher I, Blanc G, Loussouarn S
 
Drug:  Oxolinic acid
 
Fish species:  Seabass, European
 
Date:  1997
 
t1/2-hr:  87
 
Sample:  blood, plasma
 
Ave Weight (gm):  100
 
Ave Water temp (°C):  15
 
Water:  Saltwater
 
Dosage:  10 mg/kg sd
 
Route:  IV
 
Comments:  Distribution t1/2=0.69h; Vd= 2.55L/kg; Vc= 0.4L/kg Alpha t 1/2 = 0.69 h. Compared bioassay with HPLC - both similar.
 
Cl:  0.066L/kg/h
 
Vc:  0.4L/kg
 
Vd:  2.55L/kg
 
Citation:  J. Veterinary Pharmacology and Therapeutics 20:267-275
 
Link:  http://www.blackwell-synergy.com/servlet/useragent?func=synergy&synergyAction=showAbstract&doi=10.1046/j.1365-2885.1997.00062.x&area=production&prevSearch=allfield%3A%28Poher%29  Opens a new window
 
Genus Species:  Dicentrarchus labrax
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  86.6 h
 
Wt gm-detail:  100+/-10g
 
Water temp (°C)-detail:  15.2+/-0.2C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC, bioassay
 
Authors-red:  Poher I, Blanc G, Loussouarn S
 
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