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Title:  Effect of temperature on the pharmacokinetics of benzocaine in rainbow trout (Oncorhynchus mykiss) after bath exposures.
 
Authors:  Stehly GR, Meinertz JR, Gingerich WH (1998)
 
Drug:  Benzocaine
 
Fish species:  Trout, rainbow
 
Date:  1998
 
t1/2-hr:  1
 
Sample:  blood, plasma
 
Ave Weight (gm):  877
 
Ave Water temp (°C):  18
 
Water:  Freshwater
 
Dosage:  1 mg/l 4 h
 
Route:  BATH
 
Comments:  Uptake clearance and metabolic clearance increased with increased acclimation temperatures. The elimination half-life of benzocaine in plasma did not differ significantly with temperature. Vd was normalized, calculated from total volume (bath+fish). Concentration at 240 min bath = 1224 ng/ml, 2.5 min post exposure = 76 ng/ml.
 
Cl:  1.34 L/kg/h
 
Vd:  3.260 g/kg*
 
Citation:  J. Veterinary Pharmacology and Therapeutics. 21:121-127
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9597649  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Anesthetic-Benzocaine
 
t1/2-detail:  0.703+/-0.35 h
 
Wt gm-detail:  877 g
 
Water temp (°C)-detail:  18 C
 
Dosage-detail:  1 mg/l for 4 h
 
Method:  HPLC/RP
 
Authors-red:  Stehly GR, Meinertz JR, Gingerich WH (1998)
 
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