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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Pharmacokinetics and residues of norfloxacin in Lateolabras japonicus
 
Authors:  Wang Q, Liu Q, Tang X, Li J.
 
Drug:  Norfloxacin
 
Fish species:  Seabass, Japanese (Perch)
 
Date:  2004
 
t1/2-hr:  15
 
Sample:  blood, serum
 
Ave Weight (gm):  250
 
Ave Water temp (°C):  23
 
Dosage:  50 mg/kg sd
 
Comments:  T1/2 alpha=0.96h, T1/2 beta=15.1h, AUC=1.98 mg/L/h, Tmax=1.3h, Cmax=0.25 ug/mL. T1/2 beta as seen visually on a graph appears to be around 5h. Peak concentration was reached at 2h=0.39 ug/g. Norfloxacin was not detected after 48h.
 
Citation:  Journal of Fisheries of China 28:13-18
 
Genus Species:  Lateolabrax japonicus
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  15.096
 
Water temp (°C)-detail:  23.3 +/-0.6
 
Dosage-detail:  50 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Wang Q, Liu Q, Tang X, Li J.
 
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