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Title:  Absorption, distribution and excretion of the anthelmintic praziquantel (Droncit) in rainbow trout (Salmo gairdneri R.)
 
Authors:  Bjorklund HV, Bylund G (1987)
 
Drug:  Praziquantel
 
Fish species:  Trout, rainbow
 
Date:  1987
 
t1/2-hr:  30
 
est:  est
 
Sample:  liver
 
Ave Weight (gm):  325
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  500 mg/kg sd*
 
Route:  PO
 
Comments:  t1/2 estimated from graph. Bioassay using cercaria larvae of Diplostomum spathaceum. Fish first anaesthetised with MS-222. Praziquantel suspended in 1% aqueous solution of Cremophor. At 32h after administration 67%-96% of the maximum amounts of drug had been eliminated from the tissues. Drug excreted via bile and kidney.
 
Metabolites:  Unidentified metabolites, water soluble
 
Citation:  Parasitology Research 73:240-244
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3588582  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antiparasitic-Praziquantel
 
t1/2-detail:  30 h (est from graph)
 
Wt gm-detail:  150-500 gm
 
Water temp (°C)-detail:  12 C
 
Dosage-detail:  500 mg/kg sd*
 
Method:  Bioassay
 
Authors-red:  Bjorklund HV, Bylund G (1987)
 
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