Absorption, distribution and excretion of the anthelmintic praziquantel (Droncit) in rainbow trout (Salmo gairdneri R.)
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Bjorklund HV, Bylund G (1987)
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Praziquantel
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Trout, rainbow
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1987
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30
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est
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muscle
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325
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12
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Freshwater
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500 mg/kg sd*
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PO
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t1/2 estimated from graph. Bioassay using cercaria larvae of Diplostomum spathaceum. Fish first anaesthetised with MS-222. Praziquantel suspended in 1% aqueous solution of Cremophor. At 32h after administration 67%-96% of the maximum amounts of drug had been eliminated from the tissues. Drug excreted via bile and kidney.
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Unidentified metabolites, water soluble
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Parasitology Research 73:240-244
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3588582
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Oncorhynchus mykiss
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Antiparasitic-Praziquantel
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30 h (est from graph)
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150-500 gm
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12 C
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500 mg/kg sd*
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Bioassay
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Bjorklund HV, Bylund G (1987)
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