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Title:
Pharmacokinetics of acriflavine and its metabolite in rainbow trout.
Authors:
Yu Z, Vick A, Hayton WL
Drug:
Acriflavine
Fish species:
Trout, rainbow
Date:
1995
t1/2-hr:
438
Sample:
blood, plasma
Ave Weight (gm):
0
Ave Water temp (°C):
12
Water:
Freshwater
Dosage:
1.825 mg/kg sd
Route:
IVC
Comments:
Long t1/2 of acriflavine and metabolite due to large Vd. Acriflavine (14)C
Cl:
0.285 L/kg/h
Vd:
32.8 L/kg
Metabolites:
Unidentified metabolite
Citation:
Pharmaceutical Research 12:9:S-347
Link:
none
Genus Species:
Oncorhynchus mykiss
Drug Class:
Organic-Dye
t1/2-detail:
438 h
Wt gm-detail:
Not specified
Water temp (°C)-detail:
12 C
Dosage-detail:
1.75-1.90 mg/kg sd
Method:
HPLC/RP, HPLC-Rad
Authors-red:
Yu Z, Vick A, Hayton WL
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