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U.S. Department of Health and Human Services

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Title:  Toxicokinetics of parathion and paraoxon in rainbow trout after intravascular administration and water exposure.
 
Authors:  Abbas R, Schultz IR, Doddapaneni S, Hayton WL
 
Drug:  Paraoxon
 
Fish species:  Trout, rainbow
 
Date:  1996
 
t1/2-hr:  1
 
Sample:  blood, plasma
 
Ave Weight (gm):  345
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  75 ng/ml up to 120 hrs
 
Route:  BATH
 
Comments:  Concentrations ng/ml during exposure- 0.25h=70.3, 0.5h=85.6, 1h=88.7, 1.5h=92.4, 2h=101.7, 4h=104.3, 6h=103.8, 12h=102.6, 24h=101.1, 48h=99.2, 72h=98.9 (rapid uptake and then plateau).
 
Cl:  2.78 L/kg/h
 
Vd:  1.04 L/kg
 
Citation:  Toxicology and Applied Pharmacology 136:194-199
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8560474&dopt=Abstract  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Organic-Phosphorus-Pesticide
 
t1/2-detail:  0.535 h
 
Wt gm-detail:  140-550 g
 
Water temp (°C)-detail:  12 C
 
Dosage-detail:  75 ng/ml up to 120 hrs
 
Method:  GC
 
Authors-red:  Abbas R, Schultz IR, Doddapaneni S, Hayton WL
 
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