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Title:
Toxicokinetics of parathion and paraoxon in rainbow trout after intravascular administration and water exposure.
Authors:
Abbas R, Schultz IR, Doddapaneni S, Hayton WL
Drug:
Parathion
Fish species:
Trout, rainbow
Date:
1996
t1/2-hr:
56
Sample:
blood, plasma
Ave Weight (gm):
440
Ave Water temp (°C):
12
Water:
Freshwater
Dosage:
10 mg/kg sd
Route:
IVC
Comments:
Paraoxon is a metabolite of parathion; Vd for parathion = 1370 ml/kg. Catheterized fish.
Protein binding:
0.98
Cl:
0.021 L/kg/h
Vd:
1.370 L/kg
Metabolites:
Paraoxon
Citation:
Toxicology and Applied Pharmacology 136:194-199
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8560474&dopt=Abstract
Genus Species:
Oncorhynchus mykiss
Drug Class:
Organic-Phosphorus-Pesticide
t1/2-detail:
56.1 h
Wt gm-detail:
1330-550 g
Water temp (°C)-detail:
12 C
Dosage-detail:
10 mg/kg sd
Method:
GC
Authors-red:
Abbas R, Schultz IR, Doddapaneni S, Hayton WL
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