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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Pharmacokinetics and tissue residues in channel catfish Ictalurus punctatus, given intracardiac and intramuscular injections of gentamicin sulfate.
 
Authors:  Rolf LL, Setser MD, Walker JL
 
Drug:  Gentamicin
 
Fish species:  Catfish, channel
 
Date:  1986
 
t1/2-hr:  15
 
Sample:  blood, plasma
 
Ave Weight (gm):  1000
 
Ave Water temp (°C):  22
 
Water:  Freshwater
 
Dosage:  1.0 mg/kg sd
 
Route:  IM
 
Comments:  Tissue levels at 23 h ug/gm kidney= 3.4, heart 2.2, liver 1.4, bile 0.7, muscle 0.7, skin 1.2, plasma 1.2.
 
Cl:  0.035 L/kg/h
 
Vd:  0.64 L/kg
 
Citation:  Veterinary and Human Toxicology 28 (supp 1):25-31
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3509650&dopt=Abstract  Opens a new window
 
Genus Species:  Ictalurus punctatus
 
Drug Class:  Antibiotic-Aminoglycoside
 
t1/2-detail:  922+/-53 min
 
Wt gm-detail:  0.3-1.7kg
 
Water temp (°C)-detail:  22+/-2C
 
Dosage-detail:  1.0 mg/kg sd
 
Method:  Radioimmune assay
 
Authors-red:  Rolf LL, Setser MD, Walker JL
 
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