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Title:
A review of the pharmacokinetics and metabolism of sulfadimethoxine in the rainbow trout (Salmo gairdneri).
Authors:
Kleinow KM, Lech JJ
Drug:
Sulfadimethoxine
Fish species:
Trout, rainbow
Date:
1988
t1/2-hr:
17
Sample:
blood, plasma
Ave Weight (gm):
415
Ave Water temp (°C):
0
Water:
Freshwater
Dosage:
42 mg/kg sd
Route:
IVC
Comments:
Single dose = 16.9 h, multiple dose = 36.4 h, Vd= 500 ml/kg; Low magnitude, non-specific, non-saturable plasma protein binding. Residue at 4h=1.48, 12 hr= 54.18, 72 h= 9.23, 336 h= nd (ug/ml). Sulfadimethoxine-(35S).
Protein binding:
0.17
Vd:
0.50L/kg
Metabolites:
N-A-SDM, 2 polar metabolites
Citation:
Veterinary and Human Toxicology 30 (supp 1):26-30
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3212939&dopt=Abstract
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Sulfa
t1/2-detail:
16.9 h
Wt gm-detail:
180-650 g
Water temp (°C)-detail:
Not Specified
Dosage-detail:
42 mg/kg sd
Method:
Rad
Authors-red:
Kleinow KM, Lech JJ
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