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U.S. Department of Health and Human Services

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Title:  Disposition and metabolism of chloramphenicol in trout.
 
Authors:  Cravedi JP, Heuillet G, Peleran JC, Wal JM
 
Drug:  Chloramphenicol
 
Fish species:  Trout, rainbow
 
Date:  1985
 
t1/2-hr:  48
 
est:  est
 
Sample:  whole body
 
Ave Weight (gm):  225
 
Ave Water temp (°C):  17
 
Water:  Freshwater
 
Dosage:  50 mg/kg sd
 
Route:  PO
 
Comments:  % of administered dose was 26.6% at 24 h, 13.8% at 48 hr, and 8.4% at 72 hr; Covalent bonding of CP to tissue proteins (no free CP in tissues 48h after dosing). Whole carcass contained 7.5 % of initial dose after 5 days. Chloramphenicol (3H).
 
Citation:  Xenobiotica 15:2:115-121
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4002733&dopt=Abstract  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Phenicol
 
t1/2-detail:  24- 48 hr (est)
 
Wt gm-detail:  200-250g
 
Water temp (°C)-detail:  17C
 
Dosage-detail:  50 mg/kg sd
 
Method:  Rad
 
Authors-red:  Cravedi JP, Heuillet G, Peleran JC, Wal JM
 
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