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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Bioavailability, disposition and pharmacokinetics of 14C-ormetoprim in rainbow trout (Salmo gairdneri).
 
Authors:  Droy BF, Goodrich MS, Lech JJ, Kleinow KM
 
Drug:  Ormetoprim
 
Fish species:  Trout, rainbow
 
Date:  1990
 
t1/2-hr:  360
 
Sample:  blood
 
Ave Weight (gm):  500
 
Ave Water temp (°C):  14
 
Water:  Freshwater
 
Dosage:  8 mg/kg sd
 
Route:  PO
 
Comments:  15d = elimination half-life, but in a two-compartment open model, so the first phase of elimination in muscle may be smaller; Residue in muscle 12h post= 2.21 µg/g, 24h post= 1.85, 72h post= 1.64, 7d post= 0.44, 14d post= 0.32, 21d post= 0.11, 38h post= 0.15.
 
Citation:  Xenobiotica 20:2:147-157
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2333711&dopt=Abstract  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  15d (bl)
 
Wt gm-detail:  382-606g
 
Water temp (°C)-detail:  14+/-1.0C
 
Dosage-detail:  8 mg/kg sd
 
Method:  Rad
 
Authors-red:  Droy BF, Goodrich MS, Lech JJ, Kleinow KM
 
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