Patient age is the mean value of the two patients in the study.Patient gender is both 1 male and 1 female participant.Patient weight not available from the site.Event date is the accepted date of the publication.Device lot number, or serial number, unavailable.No parts have been received by the manufacturer for evaluation.Device manufacturing date is dependent on lot number/serial number, therefore, unavailable.If information is provided in the future, a supplemental report will be issued.
|
Citation: rafael romero-garcia, yaara erez, geoffrey oliver, mallory owen, sakinah merali, anujan poologaindran, robert c.Morris, stephen j.Price, thomas santarius, john suckling and michael g.Hart.Practical application of networks in neurosurgery: combined 3-dimensional printing, neuronavigation and pre-operative surgical planning.World neurosurgery.2020, 137.Https://doi.Org/10.1016/j.Wneu.2020.01.0.Background: a plethora of cutting-edge neuroimaging analyses have been developed and published, yet they have not hitherto been realized as improvements in neurosurgical outcomes.In this paper we propose a novel interface between neuroimaging and neurosurgery for aiding translational research.Our objective is to create a method for applying advanced neuroimaging and network analysis findings to neurosurgery and illustrate its application through the presentation of 2 detailed case vignettes.- methods: this interface comprises a combination of network visualization, 3-dimensional printing, and ex-vivo neuronavigation to e nable preoperative planning according to functional neuroanatomy.Clinical cases were selected from a prospective cohort study.- results: the first case vignette describes a low-grade glioma with potential language and executive function network involvement that underwent a successful complete resection of the lesion with preservation of network features.The second case describes a low-grade glioma in an apparently non eloquent location that underwent a subtotal resection but demonstrated unexpected and significant impairment in executive function postoperatively that subsequently abated during follow-up.In both examples the neuroimaging and network data highlight the complexity of the surrounding functional neuroanatomy at the individual level, beyond that which can be perceived on standard structural sequences.-conclusions: the described interface has widespread applications for translational research including preoperative planning, neurosurgical training, and detailed patient counseling.A protocol for assessing its effectiveness and safety is proposed.Finally, recommendations for effective translation of findings from neuroimaging to neurosurgery are discussed,with the aim of making clinically meaningful improvements to neurosurgical practice.Reported events: (b)(6) yr old female experienced an initial period of fatigue post-operatively that resolved within 7 days.(b)(6) yr old male experienced initial fatigue that resolved within 5 days post-operatively.Additionally, the patient experienced lower scores in design learning, design recall, immediate verbal recall, list recognition, inhibition timing, and inhibition scores.By 12 months his performance had returned to be consistent with his presurgical baseline.
|