It was reported through an article that two depression patients experienced manic episodes believed to be caused by a latent bipolar disorder triggered by the vns.The other patient is captured in mfr.Report # 1644487-2010-02812.Approximately eight months after vns implantation, this patient began to demonstrate manic episodes, cognitive changes, and sleep disturbances that were associated with vns therapy.The patient reported sleeping less than 2-3 hours per night, and he exhibited changes in his interactions with others.He was noted to be exhibiting multiple symptoms of hypomania: logorrhea, disinhibition, displaying mild irritability, and hyperkinetic behavior.No psychotic symptoms were noted.The patient was started on a mood stabilizer regimen of valproic.After this, his manic symptoms appeared to resolve.Follow-up with the patient's treating psychiatrist confirmed that he believed the manic episodes to be caused by the vns and not related to medication.He considered it a serious injury but indicated that the patient was doing well at the time of the report.He said that this was actually a good indication that the vns was working since all anti-depressants have the potential to trigger manic episodes.Prior to his vns implant, the patient had never exhibited any symptoms consistent with mania or hypomania.No further relevant information has been received to date.
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